PI4KIIIβ-IN-9 ( —— )

产品货号. M11813 CAS No. 1429624-84-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PI4KIIIβ-IN-9
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PI4KIIIβ-IN-9 是一种有效的选择性 PI4KIIIβ 抑制剂 (IC50=7 nM)。
产品描述

PI4KIIIβ-IN-9 is a potent and selective inhibitor of PI4KIIIβ (IC50=7 nM); displays >1000-fold selectivity over class I and class III PI3Ks; A KN-93 derivative with improved selectivity.
体外实验

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM) and <50% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ.
体内实验

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同义词

——
通路

PI3K/Akt/mTOR signaling
靶点

PI4K
受体

PI4K
研究领域

Cancer
适应症

——

CAS Number

1429624-84-9
分子量

487.5917
分子式

C23H25N3O5S2
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CC1=C(SC(=N1)NC(=O)C2CCCC2)C3=CC(=C(C=C3)OC)S(=O)(=O)NC4=CC=C(C=C4)O
化学全称

Cyclopentanecarboxamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-