BPN14770 (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BPN14770 (BPN-14770) 是磷酸二酯酶 4D (PDE4D) 的变构抑制剂，对人 PDE4D7 和 PDE4D3 的 IC50 分别为 7.8 和 7.4 nM。

BPN14770 (BPN-14770) is an allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 and 7.4 nM for human PDE4D7 and PDE4D3 respectively, displays 16-fold less potent against monomeric form of PDE4D lacking the UCR1 dimerization domain (PDE4D2 IC50?=?127 nM); BPN14770 is 17-fold less potent against mouse PDE4D7 (IC50?=?133 nM), binds to a primate-specific, N-terminal region of PDE4D; elevates brain cAMP and facilitates hippocampal long-term potentiation (LTP) in wild-type and humanized PDE4D mice, improves cognitive performance, antagonized the amnesic effects of scopolamine and increased cAMP signaling in brain, and increased BDNF and markers of neuronal plasticity associated with memory.Other Indication Phase 2 Clinical.

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BPN-14770

Angiogenesis

PDE

PDE

Other Indications

Other Disease

1606975-12-5

406.793

C19H14ClF3N4O

>98% (HPLC)

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O=C(N)CC1=CC=C(NC2=NC(C3=CC=CC(Cl)=C3)=NC(C(F)(F)F)=C2)C=C1

2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acetamide

(-20℃)

With Ice Pack

≥ 2 years