BI 1015550

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nerandomilast (BI 1015550) 是一种具有口服活性的 PDE4B 抑制剂，IC50 值为 7.2 nM。Nerandomilast 具有良好的安全性，在炎症、过敏疾病、肺纤维化和慢性阻塞性肺疾病 (COPD) 中有潜在应用。

Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).

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Animal Model:Rats.Dosage:0, 0.3, 1.0 and 3.0 mg/kg.Administration:Oral gavage; single dose.Result:Had minimal toxic and side effects on the intestines and stomach of rats, demonstrating biosafety.Animal Model:Male Suncus Murinus and Wistar rats; mice.Dosage:0.01, 0.1, 0.3, 1.0, 2.5 or 12.5 mg/kg.Administration:Oral gavage; single dose or twice daily for 6 days.Result:Effectively improved inflammation in lung tissue and reduced the pro-inflammatory factor TNF-α release.

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Angiogenesis

PDE

PDE

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1423719-30-5

448.97

C20H25ClN6O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 10 mg/mL (22.27 mM; 超声助溶 (<60°C)

N(C1=C2C(=NC(=N1)N3CCC(CC3)C=4N=CC(Cl)=CN4)CCS2=O)C5(CO)CCC5

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(-20℃)

With Ice Pack

≥ 2 years