Cysteamine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

肾病性胱氨酸病治疗剂和抗氧化剂；增加胱氨酸细胞的细胞内谷胱甘肽水平，也增加胱氨酸细胞的凋亡率。

An agent for the treatment of nephropathic cystinosis and an antioxidant; increases intracellular glutathione levels in cystinotic cells, also increases the rates of apoptosis in cystinotic cells; is an excellent scavenger of OH and HOCl and also reacts with H2O2; significantly increase the intracellular GSH levels; also causes autophagosome accumulation in cancer cells.Other Indication Approved(In Vitro):Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine hydrochloride administration. Cysteamine hydrochloride has antioxidant properties as a result of increasing glutathione production. Cysteamine hydrochloride is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine hydrochloride increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine hydrochloride exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine hydrochloride treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine hydrochloride to doxorubicin results in a dramatic increase in cell death.Cysteamine hydrochloride (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes.

——

——

2-Mercaptoethylamine hydrochloride

Autophagy

Autophagy

Others

Other Indications

Other Disease

156-57-0

113.6096

C2H8ClNS

>98% (HPLC)

10 mM in DMSO

C(CS)N.Cl

Ethanethiol, 2-amino-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years