Alvimopan
CAS No. 156053-89-3
Alvimopan ( ADL 8-2698 | LY 246736 )
产品货号. M12218 CAS No. 156053-89-3
一种选择性外周作用 μ-阿片类拮抗剂,IC50 为 1.7 nM,用于治疗术后肠梗阻。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ¥458 | 有现货 |
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| 5MG | ¥756 | 有现货 |
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| 10MG | ¥1188 | 有现货 |
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| 25MG | ¥2344 | 有现货 |
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| 50MG | ¥3432 | 有现货 |
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| 100MG | ¥4761 | 有现货 |
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| 500MG | ¥9630 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ¥833 | 有现货 |
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生物学信息
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产品名称Alvimopan
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述一种选择性外周作用 μ-阿片类拮抗剂,IC50 为 1.7 nM,用于治疗术后肠梗阻。
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产品描述A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved(In Vitro):Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.(In Vivo):Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
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体外实验Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 value of 1.7 nM.
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体内实验Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres produced by morphine in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
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同义词ADL 8-2698 | LY 246736
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体μ-opioidreceptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number156053-89-3
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分子量424.5326
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分子式C25H32N2O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(O)CNC([C@H](CN1C[C@H](C)[C@](C)(C2=CC=CC(O)=C2)CC1)CC3=CC=CC=C3)=O
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化学全称Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.
2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.
3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.
产品手册
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