Stauprimide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

星形孢菌素类似物，通过抑制 MYC 转录因子 NME2 的核定位来促进胚胎干细胞 (ESC) 分化。

A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription; increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues with EC50 of 0.3 uM.

——

——

N-Benzoyl-7-oxo Staurosporine

Cell Cycle/DNA Damage

c-Myc

c-Myc

——

——

154589-96-5?

584.6

C35H28N4O5

>98% (HPLC)

——

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

N-((5R,7R,8R,9S)-8-methoxy-9-methyl-14,16-dioxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

(-20℃)

With Ice Pack

≥ 2 years