10074-A4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

10074-A4 是一种 c-Myc 结合化合物，与 c-Myc370-409 结合，其行为类似于“蛋白质云”周围的“配体云”，具有与非结合配体不同的特征。

10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from that of a non-binding ligand.(In Vitro):10074-A4 showed binding affinity with c-Myc370–409 with Kd of 36.3?±?9.0?μM and EC50 of 15.1?±?2.3?μM.10074-A4 arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells.

10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1?μM.10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4.10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength. Cell Viability Assay Cell Line:HL-60 cells Concentration:25 μM, 50 μM Incubation Time:24 hours Result:Arrested the cell cycle at the S-phase.

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Cell Cycle/DNA Damage

c-Myc

Ferroptosis

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312631-87-1

409.28

C18H14Cl2N2O3S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (305.41 mM)

OC(CN1C(=O)CSC1=O)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12

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(-20℃)

With Ice Pack

≥ 2 years