Nalfurafine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nalfurafine (TRK-820、TRK820) 是一种有效的选择性 κ 阿片受体激动剂，Ki 为 3.5 nM，对 μOR 的效力低 15 倍，对 δOR 的亲和力很小（Ki 分别为 53 和 1,200 nM）。

Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively); also potently binds to mutant κ(E297K), μ(K303E), κ(E297W) and κ(E297A) with Ki of 10-50 nM; inhibits forskolin-stimulated intracellular cAMP accumulation with IC50 of 0.15 nM, which is 100 fold smaller than that of U69593; produces potent antinociceptive effects in vivo.Other Indication Approved.

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TRK-820 | TRK820

Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

Other Indications

Other Disease

152657-84-6

476.5641

C28H32N2O5

>98% (HPLC)

10 mM in DMSO

CN(C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)C=CC7=COC=C7

2-Propenamide, N-[(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, (2E)-

(-20℃)

With Ice Pack

≥ 2 years