021-51111890
购物车（）
sales@molnova.cn
SNC-80
CAS No. 156727-74-1
SNC-80 ( NIH-10815 )
产品货号. M12237 CAS No. 156727-74-1
一种高度选择性的 δ-阿片受体 (δ-OR) 非肽激动剂，IC50/Ki 为 2.73/0.18 nM；显示出比 μ-阿片受体高 2,000 倍的选择性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥837 | 有现货 |
|
| 10MG | ￥1454 | 有现货 |
|
| 25MG | ￥3422 | 有现货 |
|
| 50MG | ￥4585 | 有现货 |
|
| 100MG | ￥6183 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称SNC-80
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述一种高度选择性的 δ-阿片受体 (δ-OR) 非肽激动剂，IC50/Ki 为 2.73/0.18 nM；显示出比 μ-阿片受体高 2,000 倍的选择性。
-
产品描述A highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM; displays >2,000-fold selectivity over the μ-opioid receptor; selectively activates μ-δ heteromers to produce maximal antinociception.Pain Discontinued.
-
体外实验SNC80 selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors.
-
体内实验SNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan. Animal Model:Male and female C57BL6/J mice (20-30g) injected with Sumatriptan Dosage:10 mg/kg Administration:Intraperitoneal injection; once Result:Significantly attenuated allodynia.
-
同义词NIH-10815
-
通路Endocrinology/Hormones
-
靶点Opioid Receptor
-
受体Opioid Receptor
-
研究领域Neurological Disease
-
适应症Pain
化学信息
-
CAS Number156727-74-1
-
分子量449.6
-
分子式C28H39N3O2
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 33.33 mg/mL (74.13 mM)
-
SMILESO=C(N(CC)CC)C1=CC=C([C@@H](N2[C@@H](C)CN(CC=C)[C@H](C)C2)C3=CC=CC(OC)=C3)C=C1
-
化学全称4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-benzamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Calderon SN, et al. J Med Chem. 1994 Jul 8;37(14):2125-8.
2. Bilsky EJ, et al. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66.
3. Metcalf MD, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.
产品手册
关联产品
-
MCOPPB trihydrochlri...
MCOPPB 3HClide 是一种痛敏肽受体激动剂，pKi 为 10.07。
-
UFP-101
Potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pKi = 10.24) and displays > 3000-fold selectivity over δ, μ and κ opioid receptors. Antinociceptive and opposes the action of nociceptin in vivo.
-
Nociceptin (1-13) am...
Nociceptin (1-13), amide 是一种强效激动剂阿片类受体样 1 (ORL1) 受体，对小鼠输精管的 pEC50 为 7.9，与大鼠前脑膜结合的 Ki 为 0.75 nM。
