Selonsertib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Selonsertib (GS-4997) 是一种高度选择性、有效的 ATP 竞争性 ASK1（凋亡信号调节激酶 1，MAP3K5）抑制剂，具有潜在的抗炎、抗肿瘤和抗纤维化活性；口服生物利用度。

Selonsertib (GS-4997)?is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1,?MAP3K5) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities; orally bioavailable. Steatohepatitis,Phase 3 Clinical(In Vitro):Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.

Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.

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GS-4997 | GS4997 | GS 4997

MAPK/ERK Signaling

MEK

ASK1

Other Indications

Steatohepatitis

1448428-04-3

445.4921

C24H24FN7O

>98% (HPLC)

DMSO: ≥ 31 mg/mL

CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F

Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

(-20℃)

With Ice Pack

≥ 2 years