021-51111890
购物车（）
sales@molnova.cn
MMK7 inhibitor 4a
CAS No. ——
MMK7 inhibitor 4a ( —— )
产品货号. M16995 CAS No. ——
MMK7 抑制剂 4a 是一种有效的、特异性的 MMK7 共价抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MMK7 inhibitor 4a
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述MMK7 抑制剂 4a 是一种有效的、特异性的 MMK7 共价抑制剂。
-
产品描述MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M; MMK7 inhibitor 4a formed a covalent bond to Cys218 at the end of the hinge region of MMK7; displayed an excellent selectivity profile at 1 uM against a panel of 320 kinases; potently inhibits cellular JNK at 1 uM and completely inhibited its downstream effector c-Jun with no effect on the JNK-pathway; MMK7 inhibitor 4a is a valuable probe for further investigation to elucidate the function of MKK7 in cellular studies and in vivo.
-
体外实验——
-
体内实验——
-
同义词——
-
通路MAPK/ERK Signaling
-
靶点MEK
-
受体MEK
-
研究领域——
-
适应症——
化学信息
-
CAS Number——
-
分子量456.51
-
分子式C24H24N8O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称(R)-1-(3-(5-(1-(4-acetylphenyl)-1H-1,2,3-triazol-4-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Wolle P, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.9b00102.
