Lobeline hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Lobeline HydroHClide 是一种烟碱受体激动剂，可作为 α3β2 和 α4β2 神经元烟碱受体亚型的有效拮抗剂。

Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

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Animal Model:Sprague-Dawley rats (200-250 g) Dosage:0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration Administration:Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration Result:Decreased d-methamphetamine Self-Administration.

Lobeline hydrochloride

Endocrinology/Hormones

AChR

nAChR| Nicotinic Receptor

Neurological Disease

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134-63-4

273.92

C22H27NO2·HCl

>98% (HPLC)

Water: 1g/40mL

CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.[H]Cl

2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone hydrochloride

(-20℃)

With Ice Pack

≥ 2 years