Pheniramine maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pheniramine Maleate 是一种具有抗胆碱能特性的抗组胺药，用于治疗花粉热或荨麻疹等过敏性疾病。

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.(In Vitro):Pheniramine maleate inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects.Pheniramine maleate regulates cellular Ca2+ transmembrane action, and inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM.Pheniramine maleate (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines.Pheniramine maleate (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively.(In Vivo):Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats.

Pheniramine maleate inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects.Pheniramine maleate regulates cellular Ca2+ transmembrane action, and inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM.Pheniramine maleate (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines.Pheniramine maleate (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively. They are for reference only.Cell Viability AssayCell Line:Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL Concentration:0.5, 1.0 mM Incubation Time:24 hours Result:Induced cells apoptosis with chromatin condenses and marginalizes, and nuclear debris spreaded into the cytoplasm.Cell Viability AssayCell Line:Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL Concentration:1 μM-1 mM Incubation Time:12, 24, 48 hours Result:Inhibited cell proliferation and survival in a time- and dose-dependent manner.

Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats. Animal Model:Sprague–Dawley rats (300-350 g; male) Dosage:0.30, 0.60, 0.90, 1.50, 1.75 μM Administration:Intrathecal injection; one time Result:Resulted the spinal block and displayed dose-dependent effect.Showed 100% blockades in motor function, proprioception, and nociception, with full recoveryduration of action about 41, 56, and 88 min, respectively, at 1.75 μM.

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Endocrinology/Hormones

5-HT Receptor

HT

Inflammation/Immunology

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132-20-7

356.42

C16H20N2·C4H4O4

>98% (HPLC)

Ethanol: 71 mg/mL (199.2 mM); Water: 71 mg/mL (199.2 mM); DMSO: 71 mg/mL (199.2 mM)

CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years