Desvenlafaxine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Desvenlafaxine (O-desmethylvenlafaxine) 是文拉法辛的主要活性代谢物，是一种来自 5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI 类）的抗抑郁药。

Desvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin-norepinephrine reuptake inhibitor (SNRI class). Desvenlafaxine may be used to treat major depressive disorder and is being studied for use in the management of vasomotor symptoms in postmenopausal women. It is formulated as an extended release tablet. FDA approved in 2008. (In Vitro):Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine also induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme.(In Vivo):Desvenlafaxine (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis.

Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine also induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme.

Desvenlafaxine (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis. Animal Model:Male rats.Dosage:30 mg/kg.Administration:Orally.Result:Significantly increased extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis.

Desvenlafaxine | DVS 233 | MDD-XR

Endocrinology/Hormones

5-HT Receptor

5-HT| Norepinephrine (NE)

Neurological Disease

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93413-62-8

263.38

C16H25NO2

>98% (HPLC)

Ethanol: 3 mg/mL (11.39 mM); DMSO: 37 mg/mL (140.48 mM)

CN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years