Y-27632 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Y-27632 2盐酸盐是一种选择性 ROCK1 (p160ROCK) 抑制剂，在无细胞测定中 Ki 为 140 nM。

Y-27632 2hydrochloride is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.(In Vitro):Y-27632 (1-5 μM; 0-60 min) promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs) .Y-27632 (1-5 μM; 0-60 min) induces the expression of NSE, MAP-2 and nestin in ADSCs .(In Vivo):Y-27632 (oral gavage; 30 mg/kg; once daily; 4 w) prevents dimethylnitrosamine-induced hepatic fibrosis in rats.Y-27632 (oral gavage; 5-10 mg/kg; once) shows antiepileptic effects in epilepsy induced by PTZ and MES.

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Cell Cycle/DNA Damage

ROCK

ROCK1 (p160ROCK)| ROCK2

Cancer

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129830-38-2

320.26

C14H21N3O·2HCl

>98% (HPLC)

Water: 14 mg/mL (43.71 mM); DMSO: 64 mg/mL warmed (199.83 mM)

C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years