Itopride hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Itopride Hydrochloride 是一种 AChE 抑制剂（乙酰胆碱酯酶）和 D2DR 抑制剂。

Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor. (In Vitro):Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.(In Vivo):Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min.

Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.

Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min. Animal Model:Male ddY-strain mice (23.7-28.5 g)Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg Administration:Oral administration Result:Accelerated gastric emptying at 30 mg/kg dose.Animal Model:Male ddY-strain mice (23.7-28.5 g)Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg (Pharmacokinetic Analysis)Administration:Oral administrationResult:Cmax (358 ‰), T1/2 (24.9 min) at 30 mg/kg dose.

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Endocrinology/Hormones

AChR

AChE

Neurological Disease

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122892-31-3

394.9

C20H27CLN2O4

>98% (HPLC)

DMSO: 52mg/mL

Cl.COC1=C(OC)C=C(C=C1)C(=O)NCC1=CC=C(OCCN(C)C)C=C1

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(-20℃)

With Ice Pack

≥ 2 years