Acetamiprid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

啶虫脒是一种烟碱型乙酰胆碱受体 (nAChR) 激动剂。啶虫脒是一种全球使用的新烟碱类杀虫剂。它被证明与神经肌肉和生殖疾病有关。

Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders. Acetamiprid decreases in body weight and mildly affected spermatogenesis. Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats. Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice.

——

Acetamiprid decreases in body weight and mildly affected spermatogenesis. Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice.Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats. Animal Model:Male Sprague Dawley (SD) ratsDosage:10 mg/kg, 30 mg/kg Administration:Oral gavage; daily; for 35 days Result:Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.

——

Endocrinology/Hormones

AChR

nAChR

——

——

135410-20-7

222.67

C10H11ClN4

>98% (HPLC)

DMSO:97 mg/mL (435.62mM)

CN(Cc1ccc(Cl)nc1)C(C)=NC#N

——

(-20℃)

With Ice Pack

≥ 2 years