BYK191023 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BYK191023 diHClide (BYK-191023) 是一种有效的、高选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC50 为 86 nM。

BYK191023 dihydrochloride (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM); exhibits an affinity for iNOS, nNOS, and eNOS of 450 nM, 30 uM, and >500 uM, respectively; inhibits cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells with IC50 values 40- to 100-fold higher than at the isolated enzyme; dose-dependently suppresses the LPS-induced increase in plasma nitrate/nitrite (NO(x)) levels with ED50 of 14.9 micromol/kg/h, partially restores normal blood pressure responses to norepinephrine and sodium nitroprusside in model of LPS-induced vascular hyporesponsiveness.

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BYK-191023

Immunology/Inflammation

NOS

NOS

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1216722-25-6

327.209

C14H16Cl2N4O

>98% (HPLC)

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COC1=CC(CCC2=NC3=NC=CC=C3N2)=NC=C1.[H]Cl.[H]Cl

2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years