Epimagnolin B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Epimagnolin B 具有抗炎活性，它可以通过抑制 I-kappaB-α 降解和 NF-p65 亚基的核转位来抑制 NO 和 PGE(2) 的产生以及相应酶 iNOS 和 COX-2 的表达。

Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as Epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia.

Epimagnolin B exhibits antiallergic effects without affecting the viability of BMMCs.

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Immunology/Inflammation

NOS

NO Synthase|PGE|p65

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1134188-26-3

416.46

C23H28O7

>98% (HPLC)

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[H][C@@]12CO[C@H](c3cc(OC)c(OC)c(OC)c3)[C@]1([H])CO[C@H]2c1cc(OC)cc(OC)c1

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(-20℃)

With Ice Pack

≥ 2 years