JNJ-42041935 ( JNJ42041935 )

产品货号. M10673 CAS No. 1193383-09-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JNJ-42041935
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JNJ-42041935 是一种有效、选择性、2-OG 竞争性、可逆的 HIF-PHD 抑制剂。
产品描述

JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively; shows highly selectivity for PHD relative to FIH (pIC50=4.0); JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB; reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.
体外实验

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体内实验

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同义词

JNJ42041935
通路

Angiogenesis
靶点

HIF/HIF Prolyl-hydroxylase
受体

PHD1|PHD2|PHD3
研究领域

Inflammation/Immunology
适应症

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CAS Number

1193383-09-3
分子量

346.6493
分子式

C12H6ClF3N4O3
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 36 mg/mL
SMILES

ClC1=CC2=C(NC(N3C=C(C(O)=O)C=N3)=N2)C=C1OC(F)(F)F
化学全称

1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-

1. Barrett TD, et al. Mol Pharmacol. 2011 Jun;79(6):910-20.

计算器

产品手册

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