HIF2α-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HIF2α-IN-2 是一种有效的、选择性的 HIF-2α PAS-B 结构域变构抑制剂，Kd 为 81 nM。

HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function; antagonizes HIF-2 heterodimerization and DNA-binding activity in vitro and in cultured cells, reducing HIF-2 target gene expression.

Cell Proliferation Assay Cell Line:HPF cells in hypoxic conditions Concentration:0-100?μM Incubation Time:72 hours Result:Showed greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions.

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TCS 7009 | TC S 7009 | TC-S 7009

Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF/HIF Prolyl-hydroxylase

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1422955-31-4

308.653

C12H6ClFN4O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (162.00 mM)

O=[N+](C1=C(NC2=CC(F)=CC(Cl)=C2)C=CC3=NON=C31)[O-]

N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine

(-20℃)

With Ice Pack

≥ 2 years