IOWH-032 ( iOWH-032 | IOWH032 | IOWH 032 )

产品货号. M10658 CAS No. 1191252-49-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IOWH-032
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型、有效的 CFTR 抑制剂 (IC50=1.01 uM)，在基于 T84 和 CHO-CFTR 细胞的检测中用于治疗囊性纤维化；可能作为开发治疗囊性纤维化新药的先导化合物。
产品描述

A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.(In Vitro):IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells.
体外实验

IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells. Western Blot Analysis Cell Line:CFBE41o- cells Concentration:10 μM Incubation Time:0, 24, 48, 72 h Result:Increased the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells in a time-dependent manner.
体内实验

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同义词

iOWH-032 | IOWH032 | IOWH 032
通路

Apoptosis
靶点

CFTR
受体

CFTR
研究领域

Other Indications
适应症

Other Disease

CAS Number

1191252-49-9
分子量

545.1802
分子式

C22H15Br2N3O4
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3
化学全称

1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-

1. Cui G, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207.

计算器

产品手册

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