Dofetilide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dofetilide (UK 68789)，作为 III 类抗心律失常活性分子，是一种具有口服活性、有效的且特异性的?IKr?阻滞剂。Dofetilide 可用于心血管疾病研究。

Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.(In Vitro):Dofetilide (3~100 μg/kg; i.v.) increases repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.Dofetilide is metabolized by CYP3A4 to a mixture of inactive polar metabolites that are then excreted by the kidney.

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Animal Model:Adult beagle dogs (13-15 kg) Dosage:3~100 μg/kg Administration:I.v.Result:Increased repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.

Tikosyn | UK 68789

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

Cardiovascular Disease

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115256-11-6

441.56

C19H27N3O5S2

>98% (HPLC)

DMSO:88 mg/mL warmed (199.29 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

CS(=O)(NC1=CC=C(OCCN(CCC2=CC=C(NS(=O)(C)=O)C=C2)C)C=C1)=O

N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide

(-20℃)

With Ice Pack

≥ 2 years