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PAP-1
CAS No. 870653-45-5
PAP-1 ( 5-(4-Phenoxybutoxy)psoralen )
产品货号. M24882 CAS No. 870653-45-5
PAP-1 是一种选择性、口服活性的 Kv1.3 阻滞剂 (EC50: 2 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥436 | 有现货 |
|
| 5MG | ￥692 | 有现货 |
|
| 10MG | ￥1169 | 有现货 |
|
| 25MG | ￥2539 | 有现货 |
|
| 50MG | ￥2957 | 有现货 |
|
| 100MG | ￥4194 | 有现货 |
|
| 200MG | ￥5967 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥531 | 有现货 |
|
生物学信息
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产品名称PAP-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PAP-1 是一种选择性、口服活性的 Kv1.3 阻滞剂 (EC50: 2 nM)。
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产品描述PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
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体外实验PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM. Cell Proliferation Assay Cell Line:CCR7-TEM cells (anti-CD3 Ab stimulated)Concentration:2, 10, 25, 100 nM Incubation Time:30 minutes Result:Suppresses the Proliferation of CCR7-TEM cells with IC50 of 10 nM.
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体内实验PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats. Animal Model:9- to 11- week-old female Lewis rats Dosage:Intraperitoneal injection; three times daily for 48 hours Administration:0.3, 1, 3 mg/kg Result:Dose-dependently suppressed the DTH reaction.
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同义词5-(4-Phenoxybutoxy)psoralen
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Kv1.3 channels
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研究领域——
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适应症——
化学信息
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CAS Number870653-45-5
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分子量350.36
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分子式C21H18O5
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纯度>98% (HPLC)
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溶解度DMSO:48 mg/mL (137 mM; Need ultrasonic);Water:Insoluble
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SMILESO=C(C=C1)Oc2c1c(OCCCCOc1ccccc1)c(cco1)c1c2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68(5):1254-70.
产品手册
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