BIX02189 (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BIX02189 是 MEK5 的选择性抑制剂，IC50 为 1.5 nM，在无细胞测定中也抑制 ERK5 催化活性，IC50 为 59 nM。

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

——

——

——

MAPK/ERK Signaling

ERK

ERK5| MEK1| MEK2| MEK5| TGFβR1

Cancer

——

1094614-85-3

440.54

C27H28N4O2

>98% (HPLC)

Ethanol: 80 mg/mL (181.59 mM); DMSO: 60 mg/mL warmed (136.19 mM)

CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4

——

(-20℃)

With Ice Pack

≥ 2 years