PDK1 inhibitor 7

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性 PDK1 抑制剂，IC50 为 1 nM。

A potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases; specifically inhibits cellular PDK1 T-loop phosphorylation (Ser-241), inhibits p-RSK S221 in PC-3 cells with EC50 of 300 nM, inhibits colony formation in a subset of cancer cell lines (4 of 10) and primary xenograft tumor lines (9 of 57).

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PDK1 inhibitor MP7

PI3K/Akt/mTOR signaling

PDK

PDK

Cancer

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1001409-50-2

516.505

C28H22F2N4O4

>98% (HPLC)

DMSO : ≥ 100 mg/mL 193.61 mM;H2O : < 0.1 mg/mL

C1=CC=C(C=C1)C(COC2=CC3=C(C=C2)NC(=O)N3)NC(=O)C4=CC=CN(C4=O)CC5=CC(=C(C=C5)F)F

(R)-1-(3,4-difluorobenzyl)-2-oxo-N-(2-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)-1-phenylethyl)-1,2-dihydropyridine-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years