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VER-246608
CAS No. 1684386-71-7
VER-246608 ( —— )
产品货号. M23757 CAS No. 1684386-71-7
VER-246608 是一种有效的 ATP 竞争性丙酮酸脱氢酶激酶抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥680 | 有现货 |
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| 5MG | ￥1093 | 有现货 |
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| 10MG | ￥1729 | 有现货 |
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| 25MG | ￥3246 | 有现货 |
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| 50MG | ￥4622 | 有现货 |
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| 100MG | ￥6507 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1340 | 有现货 |
|
生物学信息
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产品名称VER-246608
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述VER-246608 是一种有效的 ATP 竞争性丙酮酸脱氢酶激酶抑制剂。
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产品描述VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
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体外实验——
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体内实验——
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同义词——
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通路PI3K/Akt/mTOR signaling
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靶点PDK
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受体PDK1|PDK2|PDK3|PDK4
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研究领域——
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适应症——
化学信息
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CAS Number1684386-71-7
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分子量552.96
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分子式C28H23ClF2N4O4
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (180.84 mM; Need ultrasonic)
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SMILESO=C(C1=CC=C(O)C=C1O)N(CC2=CC=C(CNC(C(F)F)=O)C=C2)C(C=C3)=CC=C3C4=NC(Cl)=NC=C4C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Moore JD, et al. VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget. 2014 Dec 30;5(24):12862-76.
产品手册
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