IMS2186

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂。IMS2186 使癌细胞周期阻滞在 G2/M 期，由此发挥抗增殖和抗血管生成作用。IMS2186 无眼内毒性，并能够减少眼睛渗漏和病变细胞的数量。

IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells.

Cell Cycle Analysis Cell Line:Cancer H460 cells Concentration:3 μM, 10 μM Incubation Time:Result:Showed anti-proliferative activity mediated by arresting cell cycle at G2/M.

Animal Model:Rat model of laser induced CNV Dosage:100 μg/eye, 2.0 μL of the solution of 50 μg/μL Administration:Intravitreal injection; single dose Result:Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement.

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Others

Other Targets

Others

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1031206-36-6

296.32

C18H16O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 66.67 mg/mL (224.99 mM; 超声助溶 )

COc1ccc(\C=C2/COc3ccc(C)cc3C2=O)cc1O

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(-20℃)

With Ice Pack

≥ 2 years