Endothall

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一水合物为无色晶体形式。无腐蚀性。用作选择性除草剂。

The monohydrate is in the form of colorless crystals. Non corrosive. Used as a selective herbicide.

Endothall, an organic acid, is the least toxic structural analogue of Cantharidin that still inhibits PP2A. Endothall inhibits preferentially hepatocellular carcinoma (HCC) growth and these new rat hepatocellular carcinoma lines may be useful for further biochemical and pharmacological studies on PP2A inhibitors, and for testing new forms of treatment of hepatic cell carcinomas. The HR-2, HR-3, HR-4, and Zajdela hepatocellular carcinomas are most sensitive to Endothall (IC50 of 1.7, 1.2, 0.9, and 1.7 μg/mL), whereas newborn rat hepatocytes growing exponentially in primary culture (IC50=6.2 μg/mL), rat DHD/K12 colon carcinoma cells (IC50=3.6 μg/mL), or human HT-29 colon carcinoma cells (IC50=4.9 μg/mL) were less sensitive. Endothall inhibits the growth of HCC lines in culture more than that of normal hepatocytes or colon carcinomas, inducing mitotic arrest, followed by cell death. Endothall causes dose- and time-dependent cytostasis specifically in G2/M. Endothall (3 μg/mL) inhibits the cell cycle at G2/M and subsequent apoptotic cell death.

Endothall exhibits acute LD50 of 14 mg/kg in mice.

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Metabolic Enzyme/Protease

Dehydrogenase

Others

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145-73-3

186.16

C8H10O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (537.17 mM)

OC(=O)C1C(C2CCC1O2)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years