DHODH-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DHODH-IN-1 是一种有效的二氢乳清酸脱氢酶 (DHODH) 抑制剂，IC50 为 25 nM。

DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.(In Vitro):DHODH-IN-1 (4-100 nM) prevents the measles virus from replicating in cells. When transfecting cells with ssRNA molecules, DHODH-IN-1 (0.008-5 μM) can increase the expression of ISRE luciferase reporter gene. DHODH-IN-1 inhibits Jurkat cell proliferation with an IC50 value of 0.02 μM.(In Vivo):The t1/2 for DHODH-IN-1 is 27–41 min.

DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM). DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules. Cell Proliferation Assay Cell Line:Jurkat cells Concentration:0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 μM Incubation Time:72 hours Result:Strongly inhibited Jurkat cells proliferation (IC50=0.02 μM).

DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min.

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Metabolic Enzyme/Protease

Dehydrogenase

N-acylethanolamine acid amidase (NAAA)

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1800296-63-2

403.405

C21H20F3N3O2

>98% (HPLC)

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CC(C)Oc1nn(c(C)c1Oc1c(F)cccc1F)-c1ncc(cc1F)C1CC1

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(-20℃)

With Ice Pack

≥ 2 years