Daunorubicin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Daunorubicin 是有效的拓扑异构酶 II (Topo II) 抑制剂，通过嵌入和抑制癌细胞中的大分子生物合成与 DNA 相互作用。

Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells; Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma; Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).Chemotherapeutic Agents Approved.

Daunorubicin (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells. Daunorubicin (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line). Cell Viability Assay Cell Line:Molt-4 cells (a human T-lymphoblastic leukemia cell line), L3.6 cells (metastatic human pancreatic cell line) Concentration:7 nM-1.9 μM Incubation Time:72 h Result:Inhibited cell viability with IC50 values of 40 nM (Molt-4) and 400 nM (L3.6).Apoptosis Analysis Cell Line:L3.6 cells Concentration:0.4 μM Incubation Time:24 h, 48 hResult:Induced necrosis without apoptosis at 24 h, induced both an apoptotic and extensive necrotic response at 48 h.Western Blot Analysis Cell Line:K562 cells Concentration:2 μM Incubation Time:24 h Result:Enabled the switch of LC3-I into LC3-II, accompanied with a significant increased expression level of LC3.

Daunorubicin (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice. Animal Model:Male Sprague-Dawley rats Dosage:3 mg/kg Administration:Intravenous injection, three times at 48 h intervals.Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.

RP13057 | Daunomycin | Rubidomycin

Antibody Drug Conjugates (ADC)

ADC Cytotoxin

ADC Cytotoxin

Cancer

Chemotherapeutic

20830-81-3

527.5198

C27H29NO10

>98% (HPLC)

10 mM in DMSO

CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-

(-20℃)

With Ice Pack

≥ 2 years