Daminozide ( Alar | Aminozide | B 995 | DIMG | DMASA | Kylar | SADH | Succinic Acid )

产品货号. M12281 CAS No. 1596-84-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Daminozide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Daminozide(DMASA; DIMG; B 995) 是一种植物生长调节剂，选择性抑制 KDM2/7 JmjC 亚家族。
产品描述

Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.(In Vitro):Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases).(In Vivo):Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster.
体外实验

Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases).
体内实验

Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster.
同义词

Alar | Aminozide | B 995 | DIMG | DMASA | Kylar | SADH | Succinic Acid
通路

Chromatin/Epigenetic
靶点

Histone Demethylase
受体

KDM2/7 JmjC
研究领域

Cancer
适应症

——

1.Reed DJ, Moore TC, Anderson JD. Science. 1965 Jun 11;148(3676):1469-71.

计算器

产品手册

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