Vafidemstat ( ORY 2001 | ORY-2001 | ORY2001 | Vafidemstat )

产品货号. M11465 CAS No. 1357362-02-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Vafidemstat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Vafidemstat 是一种新型强效、选择性赖氨酸特异性组蛋白去甲基酶 (LSD1) 抑制剂。
产品描述

Vafidemstat is a novel potent, selective lysine-specific histone demethylase (LSD1) inhibitor.
体外实验

Vafidemstat (ORY-2001), a dual LSD1/MAO-B inhibitor, is a novel epigenetic agent for the treatment of neurodegenerative diseases. LSD1 is a protein that participates in transcription regulation complexes; its modulation can be used to tweak transcriptional imbalances in neurodegenerative disease and redress neuroinflammation and cognitive deficit. Vafidemstat (ORY-2001) can be used in the treatment of Alzheimer's disease.
体内实验

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同义词

ORY 2001 | ORY-2001 | ORY2001 | Vafidemstat
通路

Chromatin/Epigenetic
靶点

Histone Demethylase
受体

Histone Demethylase
研究领域

——
适应症

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CAS Number

1357362-02-7
分子量

336.395
分子式

C19H20N4O2
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 50 mg/mL (148.64 mM)
SMILES

[H][C@@]1([C@@](NCC2=NN=C(N)O2)([H])C1)C(C=C3)=CC=C3OCC4=CC=CC=C4
化学全称

1,3,4-Oxadiazole-2-methanamine, 5-amino-N-[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]-