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DHODH-IN-12
CAS No. 1263303-93-0
DHODH-IN-12 ( —— )
产品货号. M32884 CAS No. 1263303-93-0
DHODH-IN-12 (Compound 12b) 是一种 Leflunomide 衍生物，也是一种二氢乳清酸脱氢酶 (DHODH) 的弱抑制剂，其 pKa 为 5.07。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1512 | 有现货 |
|
| 5MG | ￥2164 | 有现货 |
|
| 10MG | ￥3190 | 有现货 |
|
| 25MG | ￥4629 | 有现货 |
|
| 50MG | ￥6475 | 有现货 |
|
| 100MG | ￥8645 | 有现货 |
|
| 500MG | ￥17366 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DHODH-IN-12
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DHODH-IN-12 (Compound 12b) 是一种 Leflunomide 衍生物，也是一种二氢乳清酸脱氢酶 (DHODH) 的弱抑制剂，其 pKa 为 5.07。
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产品描述DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of5.07.
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体外实验Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体Dehydrogenase
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研究领域——
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适应症——
化学信息
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CAS Number1263303-93-0
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分子量203.2
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分子式C10H9N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESN(C(/C(/C#N)=N/O)=O)C1=CC=C(C)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.?
