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BC-1258
CAS No. 1507370-40-2
BC-1258 ( —— )
产品货号. M23649 CAS No. 1507370-40-2
BC-1258 是一种独特的小分子 F-box/LRR 重复蛋白 2 (FBXL2) 激活剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥381 | 有现货 |
|
| 10MG | ￥616 | 有现货 |
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| 25MG | ￥1320 | 有现货 |
|
| 50MG | ￥2130 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BC-1258
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BC-1258 是一种独特的小分子 F-box/LRR 重复蛋白 2 (FBXL2) 激活剂。
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产品描述BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
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体外实验Cell Cycle Analysis Cell Line:MLE cells Concentration:2, 10, 50 μg/mL Incubation Time:16 hours Result:Significantly increased the cell population within the G2/M phase.Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.Western Blot Analysis Cell Line:U937, K562 and THP1 cells Concentration:2, 10 μg/mL Incubation Time:16 hours Result:Increased FBXL2 protein levels.Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
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体内实验BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice.
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同义词——
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通路Others
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靶点Other Targets
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受体FBXL2
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研究领域——
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适应症——
化学信息
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CAS Number1507370-40-2
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分子量406.57
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分子式C22H22N4S2
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESC1=CC(=CC=C1CNCCNCC2=CC=C(C=C2)C3=NC=CS3)C4=NC=CS4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chen B B , Glasser J R , Coon T A , et al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis[J]. Cell Death & Disease, 2013, 4(8):e759.
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