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Acemetacin

CAS No. 53164-05-9

Acemetacin ( Acemetacin | Rantudil | K 708 | K-708 | K708 )

产品货号. M14887 CAS No. 53164-05-9

Acemetacin (Emflex) 是一种非甾体类抗炎药,是一种环氧合酶抑制剂吲哚美辛的乙醇酸酯。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
200MG ¥235 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Acemetacin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Acemetacin (Emflex) 是一种非甾体类抗炎药,是一种环氧合酶抑制剂吲哚美辛的乙醇酸酯。
  • 产品描述
    Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.(In Vitro):Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin (TVX 1322), a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of Acemetacin (TVX 1322) is that it reduces gastric damage when compared to indometacin.
  • 体外实验
    Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin (TVX 1322), a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of Acemetacin (TVX 1322) is that it reduces gastric damage when compared to indometacin. From Wikipedia.
  • 体内实验
    ——
  • 同义词
    Acemetacin | Rantudil | K 708 | K-708 | K708
  • 通路
    Chromatin/Epigenetic
  • 靶点
    COX
  • 受体
    COX
  • 研究领域
    Inflammation/Immunology
  • 适应症
    ——

化学信息

  • CAS Number
    53164-05-9
  • 分子量
    415.82
  • 分子式
    C21H18ClNO6
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 58 mg/mL warmed (139.48 mM); DMSO: 83 mg/mL (199.6 mM)
  • SMILES
    O=C(OCC(O)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
  • 化学全称
    1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Chávez-Pi?a AE, et al. Br J Pharmacol, 2008, 155(6), 857-864.
产品手册
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    Acemetacin (Emflex) 是一种非甾体类抗炎药,是一种环氧合酶抑制剂吲哚美辛的乙醇酸酯。