首页- 产品 - Immunology/Inflammation - IRAK

IRAK

The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways.IL-1/TLR signalling pathways and the IRAK family are critical in anti-pathogen responses, inflammation and autoimmunity. The family comprises of four members, IRAK-1, IRAK-2, IRAK-M (IRAK-3) and IRAK-4, and has a role in both positive and negative regulation of signal transduction.Two are active kinases, IRAK-1 and IRAK-4, and two are inactive, IRAK-2 and IRAK-M, but all regulate the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.IRAK family members have been implicated in certain disease models including human immunodeficiencies.

References

1.Flannery S, Bowie AG.Biochem Pharmacol. 2010 Dec 15;80(12):1981-91. doi: 10.1016/j.bcp.2010.06.020.

Immunology/Inflammation

Amino Acids and Derivatives(42) Antiviral(78) CD110(2) Cell wall(0) Complement System(33) FLAP(9) Hydroxylase(14) Interferon Receptor(6) IRAK(24) IκB kinase (IKK)(41) Lipoxygenase(53) LTR(13) MyD88(6) NOS(88) PD-1/PD-L1(38) PGE synthase(14) RLR(4) ROS(61) Scavenger Receptor(2) SphK(3) STING(27) TLR(69)