ζ-Stat ( NSC37044 )

产品货号. M14112 CAS No. 3316-02-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ζ-Stat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ze-Stat（1,3,6-萘三磺酸）是一种新型 PKC-zeta (PKC-ze) 特异性抑制剂，IC50 为 5 uM。
产品描述

ζ-Stat (1,3,6-Naphthalenetrisulfonic acid) is a novel PKC-zeta (PKC-ζ) specific inhibitor with IC50 of 5 uM, showed only 13% inhibition on PKC-I at 20 uM; downregulates TNF-α induced NF-κB translocation to the nucleus there by inducing apoptosis, significantly decreases melanoma cell proliferation of SK-MEL-2 and MeWo.
体外实验

:Cell Proliferation Assay Cell Line:MEL-F-NEO, SK-MEL-2 and MeWo cellsConcentration:0.1, 0.5, 1, 2.5, 5, 7.5, 10 μM Incubation Time:3 days Result:Decreased proliferation by 47.7% for 5 μM in SK-MEL-2 cells and by 50.6% for 5 μM in MeWo cells.Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM.Western Blot Analysis Cell Line:SK-MEL-2 and MeWo cells Concentration:5 μM Incubation Time:3 days Result:Decreased phosphorylated and total PKC-ζ levels.
体内实验

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同义词

NSC37044
通路

Angiogenesis
靶点

PKC
受体

PKC
研究领域

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适应症

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1. Islam SMA, et al. Biochim Biophys Acta. 2018 Apr;1865(4):650-664. 2. Ratnayake WS, et al. Cell Adh Migr. 2018 May 21:1-17.

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