β-Neo-Endorphin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

β-Neo-Endorphin 是一种内源性阿片肽。β-Neo-Endorphin 是一种起源于猪的下丘脑“大”亮氨酸脑啡肽。β-Neo-Endorphin 可激活 Erk1/2, MMP-2 和 MMP-9。

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9.

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β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes.β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes.β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9. β-Neo-Endorphin (12 h) stimulates migration in the fibroblast.Cell Viability Assay Cell Line:Human keratinocytes (HaCaT)Concentration:0, 5, 10 and 20 μM Incubation Time:20 h Result:Significantly increased the wound closure. Had no observable effect on cell viability.Western Blot Analysis Cell Line:Human keratinocytes (HaCaT) Concentration:0, 5, 10 and 20 μM Incubation Time:12 h Result:Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression.

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Others

Other Targets

ERK1 , ERK2 , MMP-2, MMP-9

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77739-21-0

1100.3

C54H77N13O12

>98% (HPLC)

H2O : 100 mg/mL (90.89 mM; ultraphonic)

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(-20℃)

With Ice Pack

≥ 2 years