alpha-Asarone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

α-细辛脑是一种精神活性化合物，对小鼠具有抗抑郁样活性。

Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.(In Vitro):The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.(In Vivo):The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.

The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.

The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.

α-Asarone | trans-Asarone

Others

Other Targets

HMGCR| CYP2D6| CYP3A4

Neurological Disease

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2883-98-9

208.3

C12H16O3

>98% (HPLC)

DMSO : 100 mg/mL 480.19 mM; H2O : < 0.1 mg/mL

C/C=C/c1cc(c(cc1OC)OC)OC

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(-20℃)

With Ice Pack

≥ 2 years