
Ziftomenib
CAS No. 2134675-36-6
Ziftomenib ( —— )
产品货号. M35131 CAS No. 2134675-36-6
Ziftomenib (KO-539) 是一种具有口服活性的 menin-MLL 相互作用的抑制剂,具有抗肿瘤活性 (WO2017161028A1, compound 151)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1486 | 有现货 |
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5MG | ¥2309 | 有现货 |
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10MG | ¥3165 | 有现货 |
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25MG | ¥5028 | 有现货 |
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50MG | ¥7718 | 有现货 |
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100MG | ¥11169 | 有现货 |
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200MG | ¥15071 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ziftomenib
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ziftomenib (KO-539) 是一种具有口服活性的 menin-MLL 相互作用的抑制剂,具有抗肿瘤活性 (WO2017161028A1, compound 151)。
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产品描述Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).
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体外实验The mixed-lineage leukemia (MLL) protein is a histone methyltransferase critical for the epigenetic regulation of gene transcription. Many acute leukemias, including acute myeloblastic leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed-lineage leukemia (MLL), are characterized by the presence of chimeric MLL fusion proteins that result from chromosomal translocations of the MLL gene located at chromosome 11, band q23 (11q23). MLL fusion proteins lack the original histone methyltransferase activity of the C-terminus of MLL and gain the ability to regulate transcription of numerous oncogenes, including HOX and MEIS1, resulting in increased cell proliferation and decreased cell differentiation, ultimately leading to leukemogenesis.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Histone Methyltransferase
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研究领域——
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适应症——
化学信息
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CAS Number2134675-36-6
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分子量717.871
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分子式C33H42F3N9O2S2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (139.30 mM; 超声助溶 )
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SMILESCNc1nc(NC2CCN(Cc3ccc4n(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Tao Wu, et al. Substituted inhibitors of menin-mll and methods of use. WO2017161028A1.
产品手册




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