YUM70

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YUM70 是一种有效的选择性葡萄糖调节蛋白 78 (GRP78) 抑制剂（抑制全长蛋白 GRP78 ATPase 活性的 IC50 为 1.5 μM）。

YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).?It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.?

Western Blot Analysis Cell Line:MIA PaCa-2, PANC-1 cells Concentration:0.1, 1, 2.5, 5, 10 μM Incubation Time:2, 4, 8, 24, 48 hours Result:Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.

Animal Model:8-week old female NCr nude mice were injected with MIA PaCa-2 cells Dosage:30 mg/kg Administration:I.p. 5 days a week for 7 weeks Result:Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.

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Cell Cycle/DNA Damage

GPR

GRP78

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423145-35-1

398.84

C21H19ClN2O4

>98% (HPLC)

DMSO:100 mg/mL?(250.73 mM;?Need ultrasonic)

O=C(CCC)NC(C1=CC=C2C(OCO2)=C1)C(C=C(Cl)C3=C4N=CC=C3)=C4O

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(-20℃)

With Ice Pack

≥ 2 years