YNT-185

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YNT-185 是一中非肽类的，选择性食欲素 2 型受体 (OX2R) 激动剂，对 OX2R 和 OX1R 的 EC50 分别为 0.028 和 2.75 μM。YNT-185 改善小鼠模型的发作性瘫痪症状。

YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.

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YNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice.YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.Animal Model:Male wild-type C57BL/6J mice Dosage:20, 40 mg/kg Administration:I.p.Result:Wake time was also significantly increased.

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Others

Other Targets

OX Receptor

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1804978-81-1

615.74

C33H37N5O5S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (162.41 mM; 超声助溶 )

S(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years