WYC209 ( —— )

产品货号. M20092 CAS No. 2131803-90-0

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HNMR

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产品名称

WYC209
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

WYC-209 抑制恶性鼠黑色素瘤肿瘤再生细胞的增殖（TRC，IC50：0.19 uM）。它的目标是视黄酸受体（RAR）。
产品描述

WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
体外实验

WYC-209 (10 μM; 24 hours) is able to inhibit and block growth of TRCs of human tumor cells in culture with a long-lasting effect. Apoptosis Analysis Cell Line:A2780, A549, MCF-7, MDA-MB-435s, A375 cells Concentration:10?μM Incubation Time:24 hours Result:TRCs failed to resume growth 5 days after the drug washout.
体内实验

WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases. Animal Model:Female immune-competent C57BL/6 mice Dosage:0.022, 0.22?mg/kg Administration:Intravenous injection; once every two days for 25 days Result:Four out of eight mice formed lung metastases at dose of 0.022?mg?/kg, only one out of eight mice formed lung metastases at dose of 0.22?mg/kg.
同义词

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通路

Metabolic Enzyme/Protease
靶点

Retinoid Receptor
受体

RAR
研究领域

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适应症

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1.Chen J et al. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nat Commun. 2018 Apr 11;9(1):1406.

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