WAY-118959-A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GM-90257 是一种微管乙酰化 (microtubule acetylation) 抑制剂，可直接与 α-微管蛋白结合。GM-90257 可防止 α-微管蛋白乙酰转移酶 1 (αTAT1) 募集至 α-微管蛋白中的 K40 残基。GM-90257 会导致 MDA-MB-231 细胞凋亡 (apoptosis)，对微管乙酰化水平相对较低的 MCF-10A 或 MCF-7 细胞影响较弱。

GM-90257 is a microtubule acetylation inhibitor that binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes the apoptosis of MDA-MB-231 cells with weaker effects on MCF-10A or MCF-7 cells, which have a relatively low level of microtubule acetylation.

——

——

——

Others

Other Targets

Microtubule Associated

——

——

315703-81-2

342.44

C16H14N4OS2

>98% (HPLC)

——

COC1=CC=C(NC2=NC(=CS2)C2=C(C)N=C3SC=CN23)C=C1

——

(-20℃)

With Ice Pack

≥ 2 years