Vorozole ( —— )

产品货号. M34140 CAS No. 129731-10-8

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Vorozole
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Vorozole 是一种有效的，选择性的，具有口服活性的非甾体芳香酶抑制剂。Vorozole 表现出体内抗肿瘤作用。Vorozole 具有研究乳腺癌的潜力。
产品描述

Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer.
体外实验

Vorozole inhibits aromatase activity with an IC50s of 1.4 nM inFSH-stimulated rat granulosa cells.
体内实验

Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 dayss) shows antitumor effect and increase the release of serum insulin-like growth factor (IGF)-1 and serum testosterone levels.Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice.Animal Model:Female Sprague-Dawley rats Dosage:0.08, 0.16, 0.31, 0.63 or 1.25 mg/kg Administration:Gavage; daily (starting at 43 days of age) for 77 days; given a single i.v. dose of methylnitrosourea (MNU) (50 mg/kg body wt) after 7 days Result:Caused a dose-dependent increase in body weight gain and decrease in cancer incidence, increased the insulin-like growth factor (IGF)-1, serum testosterone levels.
同义词

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通路

Metabolic Enzyme/Protease
靶点

P450
受体

P450 | Aromatase
研究领域

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适应症

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1. Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):617-21.?

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