
VU0285655-1
CAS No. 1158347-73-9
VU0285655-1 ( —— )
产品货号. M34142 CAS No. 1158347-73-9
BML-280 (VU0285655-1) 是一种有效的选择性磷脂酶 D2 (PLD2) 抑制剂。BML-280 能够防止高糖诱导的 caspase-3 裂解和细胞活力降低。BML-280 可用于类风湿关节炎的研究。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1008 | 有现货 |
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5MG | ¥1526 | 有现货 |
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10MG | ¥2527 | 有现货 |
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25MG | ¥5106 | 有现货 |
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50MG | ¥7163 | 有现货 |
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100MG | ¥9410 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称VU0285655-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BML-280 (VU0285655-1) 是一种有效的选择性磷脂酶 D2 (PLD2) 抑制剂。BML-280 能够防止高糖诱导的 caspase-3 裂解和细胞活力降低。BML-280 可用于类风湿关节炎的研究。
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产品描述BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research.
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体外实验BML-280 shows an approximately 21-fold selectivity for PLD2.BML-280 (0-0.1 μM) suppresses formyl-Met-Leu-Phe (fMLP)-stimulated PLD activity in a concentration dependent manner, with an IC50 of 0.04 ± 0.01 μM.BML-280 (0-0.3 μM) inhibits O2- generation, and the inhibition reaches a plateau (about 20 % inhibition) at around 0.01 μM to 0.3 μM.BML-280 (0-5 μM, 24 h) reduces proliferation in PLD1-deficient cells, but also in PLD2-deficient cells exposed to IGF-1 (Insulin-like growth factor 1). BML-280 inhibits mRNA levels and secretion of tumor necrosis factor-α, IL-1β and IL-8 in human periodontal ligament cells.Cell Proliferation Assay Cell Line:Wild-type, PLD1- and PLD2-deficient astrocytes Concentration:0, 50, 500, and 5000 nM Incubation Time:24 h Result:Had minor effects in wild-type and PLD2-deficient cells, but completely blocked PLD activity in PLD1-deficient cells. Caused a highly significant inhibition of glial proliferation when astrocytes were stimulated by FCS (fetal calf serum) or IGF-1, respectively. Showed non-specific effects because they inhibited cell proliferation even in PLD1/2 double knockouts at 5 μM.
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phospholipase
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受体Phospholipase | Interleukin | TNF
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研究领域——
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适应症——
化学信息
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CAS Number1158347-73-9
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分子量429.51
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分子式C25H27N5O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C2(N(CN1)C3=CC=CC=C3)CCN(CCNC(=O)C4=CC5=C(N=C4)C=CC=C5)CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Burkhardt U, et al. Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion. Eur J Pharmacol. 2015 Aug 15;761:398-404. ?
产品手册




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