VEGFR-2-IN-9

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VEGFR-2-IN-9 (KDR-in-4) 是有效的激酶插入结构域受体 (KDR/VEGFR2) 抑制剂，IC50 值为 7 nM。

VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.

KDR (kinase insert domain-containing receptor) is one of the human tyrosine kinases that has a high affinity for vascular endothelial growth factor (VEGF) and is believed to be a primary mediator of tumor-induced angiogenesis.

KDR-in-4 may prove to be useful for the treatment of a variety of ocular neovascular diseases using a convenient oral dosing regimen. At doses of 100 mg/kg, KDR-in-4 results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen induced retinopathy (OIR) models, respectively.

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Angiogenesis

VEGFR

VEGFR

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408502-06-7

391.46

C23H25N3O3

>98% (HPLC)

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O=C1NC=2C=CC=CC2C=C1C3=CC4=CC(OCCN(C)CCOC)=CC=C4N3

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(-20℃)

With Ice Pack

≥ 2 years