Triptorelin ( AY 25650 )

产品货号. M21742 CAS No. 57773-63-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Triptorelin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

曲普瑞林是一种 GnRHR 激动剂，可抑制雌二醇诱导的癌细胞增殖。
产品描述

Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively). It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM. It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day. Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
体外实验

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体内实验

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同义词

AY 25650
通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

57773-63-4
分子量

1311.45
分子式

C64H82N18O13
纯度

>98% (HPLC)
溶解度

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SMILES

CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
化学全称

Glp-His-Trp-Ser-Tyr-D-Trp-Leu- Arg-Pro-Gly-NH2

计算器

产品手册

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