Tretazicar ( CB1954 | CB-1954 | CB 1954 | Tretazicar )

产品货号. M18246 CAS No. 21919-05-1

CB1954(Tretazicar) 是一种抗癌前药，可被 NAD(P)H 醌氧化还原酶 2 激活。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥381	有现货
10MG	￥583	有现货
25MG	￥1191	有现货
50MG	￥1798	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Tretazicar
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CB1954(Tretazicar) 是一种抗癌前药，可被 NAD(P)H 醌氧化还原酶 2 激活。
产品描述

Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.
体外实验

——
体内实验

Animal Model:Female BALB/c mice (AB22-nr, SKOV3 human ovarian tumour xenograft)Dosage:80 mg/kg Administration:i.p. on days 2 and 9 Result:The median survival of the AB22-nr was 49 days. Resulted in a significant increase in survival.
同义词

CB1954 | CB-1954 | CB 1954 | Tretazicar
通路

PI3K/Akt/mTOR signaling
靶点

mTOR
受体

DNA alkylator
研究领域

Cancer
适应症

——

化学信息

CAS Number

21919-05-1
分子量

252.18
分子式

C9H8N4O5
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 125 mg/mL (495.68 mM)
SMILES

NC(=O)c1c(cc(c(c1)N1CC1)[N+](=O)[O-])[N+](=O)[O-]
化学全称

5-(aziridin-1-yl)-2,4-dinitrobenzamide

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Gui R,etal.Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR1/CB1954-induced cytotoxicity in the HepG2 cell line.Oncol Lett. 2012 Sep;4(3):566-570.

计算器

浓度计算器

摩尔计算器

分子量计算器

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